The problem, three ways
Curious
Some shapes in geometry are carved out by polynomial equations; others are known only through their holes and symmetries. The Hodge conjecture says that a particular large family of those topological features always comes from genuine algebraic shapes, tying topology to algebra.
Undergraduate
For a smooth complex projective variety X, the classes in H^(2k)(X, ℚ) that are also of Hodge type (k, k) should be exactly the rational combinations of classes of algebraic subvarieties of codimension k. The case k = 1 is the Lefschetz (1,1) theorem.
Specialist
Known cases include divisors, and curves by hard Lefschetz. The integral version is false (Atiyah and Hirzebruch), and the analogue for compact Kähler manifolds fails (Voisin). Cattani, Deligne and Kaplan proved that Hodge loci are algebraic, as the conjecture predicts.