The problem, three ways
Curious
The primes look random, but how they are spread out is governed by the zeros of a single function, the Riemann zeta function. In 1859 Bernhard Riemann guessed that those zeros all sit on one straight line. If he was right, the primes are as regular as they could possibly be. Nobody has proved it.
Undergraduate
The series ζ(s) = Σ n⁻ˢ converges for Re s > 1 and extends to the whole complex plane except s = 1. Its zeros at the negative even integers are called trivial; all the others lie in the strip 0 < Re s < 1. The hypothesis says they all have real part exactly 1/2. It is equivalent to the error in the prime number theorem being as small as O(x^(1/2+ε)).
Specialist
A positive proportion of zeros lie on the line (Selberg), raised by mollifier methods from Levinson's third to Conrey's two fifths and Pratt, Robles, Zaharescu and Zeindler's five twelfths, and in 2026 to 67.2% by an argument found by an AI system. The generalised forms for Dirichlet and automorphic L-functions are separate statements; a proof for ζ need not settle them.