The problem, three ways
Curious
The strong nuclear force is described by a quantum Yang–Mills theory. Physicists compute with it to remarkable accuracy, yet nobody has built the theory with mathematical rigour, or proved why its particles have mass when the classical waves do not.
Undergraduate
For each compact simple gauge group, construct a quantum Yang–Mills theory on ℝ⁴ satisfying axioms at least as strong as those of Wightman or of Osterwalder and Schrader, and prove it has a mass gap: the energy spectrum has nothing between the vacuum and some Δ > 0.
Specialist
Lattice gauge theory (Wilson) gives a regularisation with strong numerical evidence for confinement and a gap. Constructive field theory has built interacting theories in two and three dimensions, with partial progress in four (Balaban). Asymptotic freedom is why a continuum limit is expected to exist.